DC Comics, 2001
The first major crossover in comics history published to celebrate DC's 50th anniversary in 1985-86. I was a child when I first read this series and I was blown away by the epic storytelling and great art. While the story may read slightly dated today, and deaths of fictional characters have become more common (and seemingly no longer permanent), what this series delivered include high stakes and big changes that rocked the boat.
Love, love this. The American reprint is still ongoing at this point. The medical dramas, thrills and humor tales of the unlicensed surgeon Black Jack and his recurring cast of friends, aides and nemeses has me hooked! 
Simply wonderful. This complete edition collects all 3 books in the series.